List of Publications

32. Longbotham JE, Levy C, Johannissen LO, Tarhonskaya H, Jiang S, Loenarz C, Flashman E, Hay S, Schofield CJ, Scrutton NS. Structure and mechanism of a viral collagen prolyl hydroxylase. Biochemistry, 2015, 54, 6093-6105. (Link)

31. Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereo-selectivity of prolyl hydroxylases. Structure, 2015, 23, 639-652. (Link

30. Davydova E, Ho AYY, Malecki J, Moen A, Enserink JM, Jakobsson ME, Loenarz C, Falnes PO. Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). J. Biol. Chem., 2014, 289, 30499-30510. (Link)

29. Loenarz C#, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ#. Hydroxylation of the ribosomal decoding centre affects translational accuracy. Proc. Natl. Acad. Sci. U.S.A., 2014, 111, 4019-4024. (Link)

28. Katz MJ*, Acevedo J*, Loenarz C, Galagovsky D, Pérez-Pepe M, Thalhammer A, Sekirnik R, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman M, Ratcliffe PJ, Wappner P. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis and organ growth. Proc. Natl. Acad. Sci. U.S.A., 2014, 111, 4025-4030. (Link)

27. Singleton RS, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proc. Natl. Acad. Sci. U.S.A., 2014, 111, 4031-4036. (Link

26. Mazzon M*, Peters NE*, Loenarz C*, Krysztofinska EW, Ember SWT, Ferguson BJ, Smith GL. A mechanism for induction of a hypoxic response by vaccinia virus. Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 12444-12449. (Link
• Highlighted as Editors’ choice: Gough NR. Viral hypoxia response. Sci. Signal., 2013, 6, ec174. 
• Recommended by Faculty of 1000. (Link

25. Ge W, et al. Oxygenase catalysed ribosome hydroxylation is conserved from prokaryotes to humans. Nat. Chem. Biol., 2012, 8, 960-962. (Link
• Recommended by Faculty of 1000. (Link
Selected pre-2011 publications: 
23. Kawamura A, Loenarz C, Schofield CJ. Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry. Cell Cycle, 2011, 10, 2819-2820. (Link)

20. Loenarz C, Boleininger A, Coleman ML, Schierwater B, Holland PWH, Ratcliffe PJ, Schofield CJ. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep., 2011, 12, 63-70. (Link)
• Highlighted in: Rytkönen et al. Evolutionary origins of oxygen sensing in animals. EMBO Rep., 2011, 12, 3-4.

18. Loenarz C, Schofield CJ. Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem. Sci., 2011, 36, 7-18. (Link
16. McDonough MA, Loenarz C, Chowdhury R, Clifton I, Schofield CJ. Structural studies on human 2-oxoglutarate dependent oxygenases. Curr. Opin. Struct. Biol., 2010, 20, 659-672. (Link)

13. Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CDO, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N-dimethyl lysine demethylase. Hum. Mol. Genet., 2010, 19, 217-222. (Link
10. Loenarz C, Schofield CJ. Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem. Biol., 2009, 16, 580-583. (Link)

8. Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Evidence for a stereoelectronic effect in human oxygen sensing. Angew. Chem. Intl. Ed., 2009, 48, 1784-1787. (Link
• Highlighted in: Fujimori DG. Hypoxia sensing goes gauche. Nat. Chem. Biol., 2009, 5, 202-203. 
5. Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nat. Chem. Biol., 2008, 4, 152-156. (Link)