List of Publications

2015
32. Longbotham JE, Levy C, Johannissen LO, Tarhonskaya H, Jiang S, Loenarz C, Flashman E, Hay S, Schofield CJ, Scrutton NS. Structure and mechanism of a viral collagen prolyl hydroxylase. Biochemistry, 2015, 54, 6093-6105. (Link)

31. Horita S, Scotti JS, Thinnes C, Mottaghi-Taromsari YS, Thalhammer A, Ge W, Aik W, Loenarz C, Schofield CJ, McDonough MA. Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereo-selectivity of prolyl hydroxylases. Structure, 2015, 23, 639-652. (Link) 

2014
30. Davydova E, Ho AYY, Malecki J, Moen A, Enserink JM, Jakobsson ME, Loenarz C, Falnes PO. Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2). J. Biol. Chem., 2014, 289, 30499-30510. (Link)

29. Loenarz C#, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ#. Hydroxylation of the ribosomal decoding centre affects translational accuracy. Proc. Natl. Acad. Sci. U.S.A., 2014, 111, 4019-4024. (Link)

28. Katz MJ*, Acevedo J*, Loenarz C, Galagovsky D, Pérez-Pepe M, Thalhammer A, Sekirnik R, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman M, Ratcliffe PJ, Wappner P. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis and organ growth. Proc. Natl. Acad. Sci. U.S.A., 2014, 111, 4025-4030. (Link)

27. Singleton RS, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proc. Natl. Acad. Sci. U.S.A., 2014, 111, 4031-4036. (Link) 

2013
26. Mazzon M*, Peters NE*, Loenarz C*, Krysztofinska EW, Ember SWT, Ferguson BJ, Smith GL. A mechanism for induction of a hypoxic response by vaccinia virus. Proc. Natl. Acad. Sci. U.S.A., 2013, 110, 12444-12449. (Link) 
• Highlighted as Editors’ choice: Gough NR. Viral hypoxia response. Sci. Signal., 2013, 6, ec174. 
• Recommended by Faculty of 1000. (Link) 

2012
25. Ge W, et al. Oxygenase catalysed ribosome hydroxylation is conserved from prokaryotes to humans. Nat. Chem. Biol., 2012, 8, 960-962. (Link) 
• Recommended by Faculty of 1000. (Link) 
 
Selected pre-2011 publications: 
  
2011 
23. Kawamura A, Loenarz C, Schofield CJ. Mutations to metabolic enzymes in cancer herald a need to unify genetics and biochemistry. Cell Cycle, 2011, 10, 2819-2820. (Link)

20. Loenarz C, Boleininger A, Coleman ML, Schierwater B, Holland PWH, Ratcliffe PJ, Schofield CJ. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep., 2011, 12, 63-70. (Link)
• Highlighted in: Rytkönen et al. Evolutionary origins of oxygen sensing in animals. EMBO Rep., 2011, 12, 3-4.

18. Loenarz C, Schofield CJ. Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem. Sci., 2011, 36, 7-18. (Link) 
 
2010 
16. McDonough MA, Loenarz C, Chowdhury R, Clifton I, Schofield CJ. Structural studies on human 2-oxoglutarate dependent oxygenases. Curr. Opin. Struct. Biol., 2010, 20, 659-672. (Link)

13. Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CDO, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an N-dimethyl lysine demethylase. Hum. Mol. Genet., 2010, 19, 217-222. (Link) 
 
2009 
10. Loenarz C, Schofield CJ. Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem. Biol., 2009, 16, 580-583. (Link)

8. Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ. Evidence for a stereoelectronic effect in human oxygen sensing. Angew. Chem. Intl. Ed., 2009, 48, 1784-1787. (Link) 
• Highlighted in: Fujimori DG. Hypoxia sensing goes gauche. Nat. Chem. Biol., 2009, 5, 202-203. 
 
2008 
5. Loenarz C, Schofield CJ. Expanding chemical biology of 2-oxoglutarate oxygenases. Nat. Chem. Biol., 2008, 4, 152-156. (Link)
INFO
The Lönarz Group is part of the Faculty of Chemistry and Pharmacy, University of Freiburg. All information on this website is copyright to Lönarz Group unless otherwise stated.
ADDRESS 
Institute of Pharmaceutical Sciences
University of Freiburg
Albertstr. 25
79104 Freiburg, Germany
 
CONTACTS 
Email: christoph.loenarz@pharmazie.uni-freiburg.de
Tel. +49 (0) 761 203-6334
Fax: +49 (0) 761 203-6351